but humans keep synthesizing both IGF-I and IGF-II in adult life. Insulin receptor substrate (IRS)-1 is a multitask protein that interacts with many other proteins. IRS-1 is mitogenic, inhibits ...

Researchers studying over 2,000 Ashkenazi Jewish centenarians uncovered two rare IGF-1 gene variants linked to exceptional longevity. These variants reduce IGF-1 receptor activity through either ...

Altindis said the grant will enable him and the researchers in his lab to learn more about how to use specific viral insulins that mimic human insulin so as to inhibit IGF-1 receptor action, which is ...

Stimulation of epidermal keratinocytes by insulin-like growth factor ... as antipsoriasis therapeutic agents. Figure 1: Reduction in IGF-I receptor mRNA in HaCaT cells following treatment with ...

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system.

Crinetics Pharma's Paltusotine shows strong Phase 3 results for acromegaly. Click here to find out why CRNX stock is a Buy.