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STIM1-SOCE-NFAT 轴如何左右免疫Th1 细胞分化
为明确 SOCE 在 Th1 分化中的作用,研究人员开展 STIM1 相关研究。结果发现 STIM1-SOCE–NFAT 信号轴对 Th1 分化至关重要,且 IL-12 可挽救相关缺陷细胞的 T-bet 表达。该研究为免疫领域提供新认知,值得一读。 基质相互作用分子 1(STIM1)对于储存操纵性钙离子内流 ...
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