Most clinically relevant T-cell receptor (TCR)-engineered T cells are typically tested in immunocompromised mice, allowing human T-cell engraftment but failing to replicate the complex interactions of ...

While it did not rule out the possibility of mutation in an immunocompromised person, the paper said it was more likely to have come from a mouse host and called for increased surveillance of ...

(3, 5) Scientists took human pancreatic cancer cells and transplanted them into immunocompromised mice. The mice then received an injection of PJ34 for 14-days straight. One month later ...

It parallels earlier work done at the center to better understand how the immune systems of people who are immunocompromised respond to vaccines against SARS-CoV-2, the virus that causes COVID-19.

even for mice that were immunocompromised. “Modified BCG elicited similar immune responses and provided similar protection against Mtb challenge as wild-type BCG in mice,” the investigators wrote.

It parallels earlier work done at the center to better understand how the immune systems of people who are immunocompromised respond to vaccines against SARS-CoV-2, the virus that causes COVID-19.

Yearly administration of the influenza vaccine is the main strategy to prevent influenza in immunocompromised patients. Here, we reviewed the recent literature regarding the clinical significance ...

Relevant preclinical models are vital to ensuring that time and money are invested in advancing the most effective drug candidates. While traditional cell line-derived xenograft (CDX) models generated ...