Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

using the EphA3-specific monoclonal antibody (mAb), IIIA4, which binds and activates both human and mouse EphA3. We use two models of human pre-B-ALL to examine EphA3 function, demonstrating ...

These interactions are crucial for triggering various effector functions of the immune system. Two hinge regions link the Fab and Fc portions of each antibody molecule. There are five main types ...

HOUSE, Pa. - Johnson & Johnson (NYSE: NYSE:JNJ) has released new data on nipocalimab, an investigational drug with potential to treat diseases driven by immunoglobulin G (IgG) antibodies. Published in ...

There are many immunological diseases related to antibody functions and production of autoimmune antibodies and it is essential that their treatments be continued during pregnancy. The aim of the ...

Intravenous immunoglobulin (IVIG) is a type of medication used to treat people with immunodeficiencies, when the immune ...

IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their ...