Researchers at Cellectis leveraged gene editing to create a CAR T cell that acts in an IF/THEN system. Traditional methods to develop CAR T cells that use the patient’s cells introduce challenges ...

Scientists at the University of São Paulo analyzed blood samples donated by six serodiscordant couples where female partners were resistant to SARS-CoV-2 despite intense contact with their infected ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Mutations that disrupt the trpR gene lead to elevated production of ... they are negatively regulated by a repressor protein, but they are inducible (i.e., they can be turned on by a signal).

Oncolytic viruses are therapeutic agents used for in situ immunization in cancer immunotherapy. Unfortunately, its efficacy is particularly limited in solid tumors expressing stimulator of interferon ...