However, we have a group of ‘essential genes’ that we cannot remove because it results in cell death.” To overcome this, Adli and colleagues utilize reversible auxin-inducible degron (AID) tools that ...

It seems that proteins called hypoxia-inducible factors (HIFs) can affect gene expression in low-oxygen conditions. While some control of gene expression is mediated through control of whether a ...

Shipra Das, an immunooncologist at Cellectis, discussed a novel approach using transcription activation-like effector nucleases (TALENs) gene editing to overcome these shortcomings by making CAR T ...

Reference: MultiSite Gateway compatible cell type-specific gene inducible system for plants. Siligato R, Wang X, Yadav SR, Lehesranta S, Ma G, Ursache R, Sevilem I, Zhang J, Gorte M, Prasad K, ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Pacira BioSciences PCRX announced that it has dosed the first patient in a mid-stage study of pipeline candidate PCRX-201 ...