Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...

This, in turn, propelled NLRP3 inflammasome activation. But most notable in the lab research was that the team found a way to circumvent the problematic out-of-control proinflammatory activity.

Scientists provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease. Their findings, based on studies in cell culture, mice and tissue ...

The inflammasome is a multiprotein intracellular complex that detects pathogenic microorganisms and sterile stressors, and that activates the highly pro-inflammatory cytokines interleukin-1b (IL ...

A Potential Therapeutic Target for Steroid Resistant Asthma,” published in the December 2024 issue of Allergy and Immunology by Berkinbayeva et al. Asthma is a chronic inflammatory disease, with a ...

Scientists from DZNE, University Hospital Bonn (UKB) and the University of Bonn provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease ...

In GA, multiple toxic substances including complement, retrotransposons, amyloid β, iron, and reactive oxygen species accumulate in the eye and trigger inflammasome activation as a final common ...

More information: James R. O'Siorain et al, Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages, The FASEB Journal (2024). DOI: 10.1096/fj.202400508RR ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity ...

First subjects dosed in a Phase 2 trial of VTX3232 in participants with obesity and cardiometabolic risk factors, with topline data expected in H2 2025 Phase 2 trial of VTX2735 in participants with ...