Mariathasan et al., "Cryopyrin activates the inflammasome in response to toxins and ATP," Nature, 440:228-32, 2006. (Cited in 121 papers) The finding: By observing mice deficient in the adaptor ...

Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.

NodThera is developing a portfolio of novel, potent and selective NLRP3 inflammasome inhibitors ... of many chronic conditions and NodThera’s platform of novel NLRP3 inhibitors paves the ...