New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and ...

Many individuals are told that managing type 2 diabetes is simply a matter of controlling blood sugar. As long as glucos ...

The researchers also show that this phosphorylation affects the sensitivity of the liver to insulin, and have thus discovered ...

Around one in five Brits are thought to be living with this potentially deadly disease, although many may not even realise ...

A natural product called DLPC (dilauroyl phosphatidylcholine) increases sensitivity to insulin and reduces fatty liver in mice, leading Baylor College of Medicine researchers to believe it may provide ...

In healthy individuals, insulin signaling in the brain controls appetite ... Brain-specific effects of insulin action and fat content in the liver were assessed using MRI.

The liver-selective glucokinase activator was found to be ... submitted a comprehensive response letter clarifying that the chromatographic signal was an 'experimental artifact'. Cadisegliatin is ...