While this response might serve the organism well in situations of low nutrient availability, reduced CNS insulin action due to impaired signal transduction could potentially contribute to weight ...

which can be programmed to differentiate into insulin-producing cells. Understanding the signal transduction pathways involved in the differentiation process is vital to the success of this approach.

Aging is a nonadaptive process resulting from cumulative damage in cells, and the genes that control oxidative or other damage may have an effect on the timescale of the aging process. Insulin also ...

"T2DM is characterized by elevated blood glucose levels and insulin resistance, and its pathogenesis mainly includes pancreatic β cell dysfunction ... expanded the signal transduction between ...