Jouanguy E; Altare F; Lamhamedi S; Revy P; Emile JF; Newport M; Levin M; Blanche S; Seboun E; Fischer A; Casanova JL ...
Among its effects, SOX17 prevents cells from synthesizing the receptor that normally detects interferon gamma, a molecule that is one of the immune system's primary weapons against cancer cells.
Interferon gamma (IFN-γ) is a cytokine that induces ... actions of the cells are activated when IFN-γ binds to the IFN-γ receptor, which is made up of IFNGR1 and IFNGR2. IFN-γ expression ...
"Interferon gamma was absolutely critical for causing ... inflammation by suppressing signals downstream of the interferon receptor. When the researchers gave mice baricitinib, it suppressed ...