The two major invasive interventions for managing spasticity are administration of intravenous and intrathecal medication (discussed above) and chemodenervation. Before using invasive treatment ...

Novartis (NYSE:NVS) said a Phase 3 study of an intrathecal formulation of its ... The product, which is one of the most expensive drugs in the world, is used to treat SMA in children younger ...

Zolgensma as an intravenous infusion has been approved in the U.S. for children under 2 years with SMA since 2019. The intrathecal version injects the gene therapy directly into the spinal cord ...

Intrathecal administration ... Consider discontinuing drugs that may lower the seizure threshold (eg, phenothiazine derivatives, tricyclics, MAOIs, CNS stimulants, analeptics, antipsychotics ...

The blood–brain barrier is the biggest challenge to the development of drugs that target the CNS. Most capillary beds leak plasma contents between and across endothelial cells by way of window-like ...

intrathecal use). Ensure adequate hydration ... Consider discontinuing drugs that may lower the seizure threshold (eg, phenothiazine derivatives, tricyclics, MAOIs, CNS stimulants, analeptics ...

including cordotomy and intrathecal drug delivery Top neuromodulation center for implantation of spinal cord stimulators, dorsal root ganglion stimulators, and intrathecal pumps The proper management ...

infection of an implanted intrathecal pump can lead to meningitis. Such problems are becoming more common (Teddy, Jamous, Gardner, Wang, & Silver, 1992). Baclofen is a classic medication for ...