A research group, led by Dr. Pavel Majer from IOCB Prague, in collaboration with the laboratories of Barbara Slusher and Louis Garza at Johns Hopkins University, has developed a compound that could ...

investigated microglial metabolism as a target in TBI. They focused on itaconate, an intermediate metabolite in the tricarboxylic acid cycle, which is produced by aconitate decarboxylase (IRG1 ...

What is more, there is a good chance that the substances will be administrable orally in the form of tablets and not just as an ointment. Itaconate is a naturally occurring substance with ...

Itaconate is a naturally occurring substance with anti-inflammatory effects elicited by interacting with the immune system. However, itaconate has the weakness that it does not easily penetrate ...