Christina Applegate and Jamie-Lynn Sigler discuss differences in how they live with multiple sclerosis in an emotional ...

Jamie-Lynn Sigler’s 10-Year-Old Son Beau Leaves Hospital 33 Days After ‘Nightmare’ Diagnosis Jamie-Lynn Sigler Reveals Son Beau Has Been Diagnosed with Autoimmune Disorder After Catching a ...

In a heartfelt conversation on Hoda Kotb's Making Space podcast, Christina Applegate and Jamie-Lynn Sigler opened up about ...

“I just didn’t know what that would mean for me to say it out loud and have everybody know,” Jamie-Lynn Sigler says in PEOPLE’s exclusive clip of her and Christina Applegate’s new ...

A new episode of Hoda Kotb's podcast, “Making Space,” is out featuring Christina Applegate and Jamie-Lynn Sigler who open up ...

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Jamie-Lynn Sigler is going up against her Sopranos brother, Robert Iler, on The $100,000 Pyramid! In PEOPLE's exclusive look at the March 23 episode of the game show, the two former costars ...

Applegate revealed in an episode of the podcast "MeSsy," which she co-hosts with fellow actress Jamie-Lynn Sigler, that she's been in and out of urgent care constantly since being diagnosed with MS.

Jamie-Lynn Sigler is going up against her Sopranos brother, Robert Iler, on The $100,000 Pyramid! In PEOPLE's exclusive look at the March 23 episode of the game show, the two former costars prepare to ...

The "Dead to Me" star shared the toll that multiple sclerosis has taken on her body and digestive system since she was diagnosed in 2021.