这项研究揭示了一个小的DNA切刻如何扩展成一个大的单链DNA缺口，进而杀死BRCA突变的癌细胞，包括耐药性乳腺癌细胞。这些发现确定了癌症中一个新的“弱点”，有望成为未来治疗的靶点。

Research by UMass Chan Medical School scientists Sharon Cantor, PhD, and Jenna M. Whalen, PhD, poses a new explanation for ...

Research by UMass Chan Medical School scientists Sharon Cantor, Ph.D., and Jenna M. Whalen, Ph.D., poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells.