The authors conclude that KRAS mutation status can be used to identify the subgroup of patients with irinotecan-refractory metastatic CRC who are most likely to respond to cetuximab.

Accordingly, the researchers next plan to investigate the extent to which individual KRAS mutations influence response to EGFR inhibitors, such as cetuximab. “Future personalized patient ...

The vaccine contains synthesized peptides, which act like a signal to tell the immune system to go after and destroy cancer cells carrying two of the KRAS mutations, G12R and G12D, the most ...

The firm said it has received positive feedback from the FDA on the design of a Phase III trial of ELI-002 in KRAS-mutant pancreatic cancer.

Received supportive FDA feedback on key elements of the potential ELI-002 Phase 3 study design, including dose, schedule, ...

KRAS G12C is the most common form of KRAS mutation in lung cancer, while G12D is found more commonly in other diseases like pancreatic and colorectal cancers. Dr Hu Tao, co-founder and chief ...

A new analysis of data from the KeyNote-042 trial in previously-untreated NSCLC has shown that the drug is effective regardless of whether a patient’s tumour bears KRAS mutations – which make ...

The U.S. Food and Drug Administration approved Amgen's combination therapy on Thursday to treat colorectal cancer in patients ...

The Pfizer/BioNTech vaccine can still target a key mutation that has emerged in two new variants of coronavirus, laboratory studies show. However, this is only one of many mutations that are found ...

Additionally, Circio is actively developing a cancer vaccine, TG01, targeting KRAS mutations, with ongoing clinical trials in the USA and Norway. TipRanks is the most comprehensive data set of ...

Some scientists worry that coronavirus vaccines will not be as effective against the UK mutation (version B.1.1.7) that caused quite a stir over the weekend. The UK coronavirus mutation has been ...