Association with proteins outside the TLR family also increases diversity (for example, TLR4 recognizes LPS in association with proteins called MD2 and CD14). TLRs 1, 2, 4, 5, and 6 are located ...
LPS receptor-deleted mice (i.e., CD14 mutants) are hypersensitive to insulin, and the occurrence of insulin resistance, obesity, and diabetes is delayed in response to high-fat feeding.
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