Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer ...

In addition, Poltorak et al. (1998) demonstrated that mice with a defective version of TLR4 are completely resistant to LPS-induced sepsis. This established that TLR4 is the receptor for LPS ...

Toll-like receptor (TLR) recognition of microbial compounds initiates signalling cascades that activate inflammatory and immune-response genes. A recent report in Nature shows that the nuclear ...

We report here for the first time that high-fat feeding augments plasma LPS at a concentration sufficient to increase body weight, fasted glycemia, and inflammation. LPS infusion in normal diet ...