Though a complex interplay of genes, diet, and environment contribute, 90% of cases share one thing in common: leptin resistance. In lean individuals, fat cells produce the hormone leptin ...

Using a mouse model of the disease, May-yun Wang et al. 1 tested the effects of treating diabetes with another hormone, leptin. Leptin is secreted by fat cells and is known for modulating energy ...

In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

Though a complex interplay of genes, diet, and environment contribute, 90% of cases have leptin resistance in common. In lean individuals, fat cells produce the hormone leptin, which suppresses ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates ...