As things turned out, however, the Laboratory provided a very fertile environment—with excellent colleagues and world-class mouse models ... normal genes for leptin and its receptor, are leptin ...

Leptin, a hormone derived ... conducted experiments with mice to explore the functions of BNC2 neurons further. They used CRISPR-Cas9 technology to knock out LepR in these neurons.

In this study, researchers found that adipocyte-specific ESRRA knockout rescues ... formation in mice induced by OVX or DIO. Additionally, ESRRA positively modulates leptin expression by binding ...