脂肪肝疾病发展至肝细胞癌（HCC）的机制一直是现代医学研究中的重要课题。在2025年1月1日发表在Nature期刊上的一篇题为“FBP1 controls liver cancer evolution from senescent MASH hepatocytes”的研究中，来自华西医院和美国加州大学圣地亚哥分校的联合科研团队揭示了一个关键的酶——果糖-1,6-二磷酸酶1（FBP1）在这个过程中所 ...
2025 年的钟声刚刚敲响，四川大学已接连在 Nature、Science、Cell 三大国际顶刊上发表文章。 2025 年 1 月 1 日，四川大学古丽、重庆大学朱亚辉及加州大学圣地亚哥分校 Michael Karin 共同通讯在 Nature ...
2025年1月1日，四川大学Gu Li、Zhu Yahui及加州大学圣地亚哥分校Michael Karin共同通讯在Nature在线发表题为《FBP1 controls liver cancer ... （FBP1）是p53的靶标 ...
Loss of normal p53 function has been associated with resistance ... specific since we found that the cells in organs such as liver, lung, muscle, bone marrow, and intestinal crypts were not ...
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Persistent activation of DNA damage response in the liver after MASLD reversalMoreover, P53 knockout in mice led to downregulated expression of apoptosis signaling in the liver. Mechanistically, P53 may ...
AZoLifeSciences on MSN4 个月
New Insights into How Mutant p53 Promotes Tumor Growththe team investigated three specific p53 mutations: M237I, commonly found in glioblastoma; R249S, which is prevalent in liver cancer; and R248Q, associated with breast cancer. They found that each ...
3. Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature.
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