Soluble proteins are carried in the lumens of vesicles. Any proteins that are destined for a lysosome are delivered to the lysosome interior when the vesicle that carries them fuses with the ...

In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

The vesicle is then known as a lysosome when its contents have been digested by the cell. Exocystosis is the process of membrane transport that releases cellular contents outside of the cell.

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Even more fascinating is the intricate relationship between lysosomal exocytosis ...

The autophagosome then fuses with another type of vesicle called lysosome. The fused stage is called autolysosome. The autolysosome ultimately matures into lysosome, where the waste is degraded by ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...