CD8 + T cells can recognize and then kill HIV-infected cells following the presentation of fragments of viral proteins (epitopes) in the peptide-binding groove of MHC class I molecules on the ...

Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells. The presence of empty class II molecules on the surface of ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

These fragments are presented by countless molecular “radio masts,” or MHC-I molecules. After being put together inside the cell, they are moved to the membrane, which is the lipid layer that ...

First, investigators developed molecular probes designed to react with cysteines: protein building blocks found within peptide antigens displayed on the surface of MHC-I molecules. Next ...