研究团队发现，BRD4抑制剂JQ1能有效瓦解ecDNA转录 ... 又设置着拷贝数的安全阈值——当MYC超过200拷贝时，57%的细胞会主动进入休眠状态。

为探究乳酰化相关基因（LRGs）在心力衰竭（HF）中的作用，研究人员分析 HF 数据集（GSE5406），运用多种生物信息学方法，发现 BRD4 是关键 LRG，其诊断准确性高。该研究为探索 HF 机制、寻找新诊疗靶点奠定基础。 心力衰竭（Heart Failure，HF），这一复杂的临床 ...

更惊人的是，这种基因操控术竟自带"智慧调节"系统——当MYC拷贝超过临界值 ... 研究人员已发现用BRD4抑制剂瓦解ecDNA转录枢纽，使耐药肿瘤存活 ...

Among the different BET proteins, only BRD4 was able to activate MYC without relying on its bromodomain. When BRD4 was removed from cells, BET inhibitors completely killed cancer cells.

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...