Nature13y
Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma
1, 2 In this study, we derived and validated an MYC activation signature that is dissociated from cell cycle/proliferation and showed that this signature is activated in about two-thirds of MM but ...
Nature1mon
Integrating Myc and TGF-β signalling in cell-cycle control
Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...
The Scientist12d
Myc, Nicked
M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...
BioWorld22h
Targeting translation could be novel way to fight Myc, other oncogenes
Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published ...
The Scientist5y
Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs
Known as c-Myc, the protein is encoded by one of the first cellular ... The peptide acts as a transcription factor, promoting the expression of genes involved in the cell cycle, cell death, and ...