Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is ...
Given the central role of p53, Myc, and MCL1 in cancer progression ... proteins of interest and have clinically relevant substrate degradation profiles offering broad therapeutic opportunities.
M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...
"Because Aurora-A stabilizes N-Myc against degradation, inhibiting the interaction could represent a promising approach for anticancer drug development and our finding that peptidomimetics can ...