Researchers have uncovered a promising therapeutic target for adenoid cystic carcinoma (ACC), a rare cancer of the salivary ...

RNA-seq 分析发现，ELOVL6 抑制导致 202 个基因差异表达，GSEA 分析表明，未处理细胞在 “myc targets” 和 “cell cycle” 通路富集度更高，而脂质代谢相关通路在未处理细胞中也更富集，说明 ELOVL6 抑制使这些通路下调。细胞信号磷酸激酶阵列实验发现，细胞增殖相关 ...

This discovery is the first step toward identifying potential therapeutic targets along the pathway. This is a very powerful oncogenic pathway set off by MYC activation. We need to understand this ...