In this example, it activates an enzymatic cascade of MAP kinases. This results in potent ... activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade that relays ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling. However, the clinical efficacy of mitogen-activated protein kinase ...