Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in cancers results in the activation of several downstream pathways that are shared with other tyrosine kinases.

Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when ...

The model, which is predominantly based on genetic gain- or loss-of-function studies, implies that RAS is locked into an active state in cancer ... MEK mitogen-activated protein kinase kinase ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...