Rheumatoid arthritis (RA) is an autoimmune disorder affecting millions worldwide, causing chronic inflammation, debilitating ...

The molecular mechanisms of action, clinical development, and efficacy and safety of targeted antineoplastic drugs are discussed. Recently introduced mechanism-based systemic therapies for cancer ...

Horizon’s aim is to help its partners to identify, evaluate and validate targets, to understand drug mechanisms of action, and to facilitate studies involving patient stratification. Horizon has ...

On the other hand, mechanisms of acquired resistance to 'pathway-targeted' drugs, such as the various clinically active kinase inhibitors, have been somewhat more straightforward to elucidate and ...

The company’s ultimate goal is to develop a suite of solutions that allow short-RNA medicines to be delivered in a highly targeted ... via an ecosystem of delivery mechanisms.

A team from UNIGE, the Max Planck Institute for Molecular Physiology in Dortmund, and Heinrich Heine University in Düsseldorf ...

DNA nanorobots control artificial cell membranes, mimicking living cell functions It creates transport channels in synthetic cells to enhance drug delivery ... This mechanism was developed using ...

These solutions include molecular conjugates and nanoparticles for targeted drug delivery, new imaging modalities for surgical guidance and detection ... epigenetics-based methods to determine ...

What enables the targeted drug delivery feature is the internal pocket of fluid (dye in the experiment) and the monostable state of these origami robots. When the magnetic field is removed ...

Researchers in Geneva have determined how some harmful bacteria introduce dangerous enzymes into host cells. They now want to use this discovery to ...

By harnessing various propulsion mechanisms, nanoswimmers offer exciting opportunities for targeted drug delivery, biosensing, environmental remediation, and studying fundamental aspects of motion at ...

More information: Bassel Alsaed et al, Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment, Nature Communications (2025 ...