Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells ... in both human and mouse tissue samples. Their work showed that the small intestine holds two types of ...

Meanwhile, the adaptive system, consisting of T and B cells, responds more slowly, targeting specific antigens and generating long-lived memory cells to enable a quicker, stronger secondary response.

Immune cells called regulatory T cells have long been known for their role in countering ... the Morton Grove-Rasmussen Professor of Immunohematology in the Blavatnik Institute at HMS. The work adds ...

Developing effective treatments and understanding how the mechanism of the immune system have always been challenging for ...

Tissue-resident memory cells provide a local ... “One part of this work was discovering causal relationships between well-characterized genes and CD8 T cell spatial and transcriptional ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases.

Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors ...