Objective Many societies recommend using estimated glomerular filtration rate (eGFR) rather than serum creatinine (sCr) to determine metformin eligibility. We examined the potential impact of ...

Delphine S. Tuot; Feng Lin; Michael G. Shlipak; Vanessa Grubbs; Chi-yuan Hsu; Jerry Yee; Vahakn Shahinian; Rajiv Saran; Sharon Saydah; Desmond E. Williams; Neil R. Powe ...

Max saxagliptin 5mg/day and metformin ext-rel 2000mg/day. Renal impairment (eGFR 30–45mL/min/1.73m 2): not recommended; (eGFR <45mL/min/1.73m 2): max saxagliptin 2.5mg/day. Concomitant strong ...

All: max 100mg sitagliptin/2000mg metformin per day. Renal impairment (eGFR 30–45mL/min/1.73m 2): initiation not recommended; (if eGFR later falls <45mL/min/1.73m 2): max 50mg/day of sitagliptin.