The precise mechanism of action of metronidazole is unclear. Infuse over 1hr. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6hrs for 7–10 days; max 4g/24hrs. Bone/joint ...

Severe hepatic impairment (Child-Pugh C): reduce metronidazole dose by 50%. No dose adjustment needed for mild to moderate hepatic impairment, but monitor for metronidazole associated adverse events.

Malfertheiner et al. (2007) Europe (Maastricht III) PPI (standard dose b.i.d.) Clarithromycin (500 mg b.i.d.) Amoxicillin (1000 mg b.i.d.) or metronidazole (400 mg b.i.d.) 7–14 In populations ...

One RCT found that a single vaginal douche with hydrogen peroxide was slightly, though significantly less effective than a single oral dose of metronidazole. Conclusion The use of antiseptics and ...