研究人员针对 MFN2 变异意义不明问题，开展其对线粒体融合影响的研究，为 CMT2A 诊断提供依据。 探索线粒体融合奥秘，攻克罕见病诊断难题 在神秘的人体微观世界里，线粒体如同一个个能量工厂，为细胞的正常运转提供源源不断的动力。而线粒体的融合过程 ...

the team employed CRISPR-Cas9 gene editing to label the MFN1 and MFN2 proteins within the cell, without resorting to artificial overexpression. This approach allowed them to study mitofusins under ...

MFN2 has long been recognized for its role in mitochondrial fusion. The researchers now uncovered an additional, unexpected function of MFN2 in maintaining protein quality within cells.