Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining ...

It is believed that tau-mediated neurodegeneration might result from a combination of a loss of normal tau function (primarily the microtubule ... is likely to be associated with toxic gains ...

The microtubule-associated protein XMAP215 promotes microtubule growth, but how this occurs has been unclear. To address this question, Gary Brouhard et al. developed a single-molecule ...

Researchers investigate tauopathy mechanisms and turn to tau detection methods to help improve health care outcomes and lower the economic burden of these diseases. The microtubule-associated protein ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...