Researchers from the Mitochondrial Medicine Program at Children's Hospital of Philadelphia (CHOP) have better characterized a ...

Purpose: Accumulation of mitochondrial DNA deletions and the resultant impaired oxidative phosphorylation may play a pathogenic role in the mediation of age-related sarcopenia. Methods ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

Typically, humans inherit mitochondria and mitochondrial DNA from their mothers only. But using sequencing data from the mitochondrial genomes of members from three unrelated families, researchers ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

known today as mitochondrial DNA (mtDNA). Today mtDNA produces 13 key mitochondrial proteins. As mitochondria age, they change shape and become less active. Eventually they fail and release mtDNA.

It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA (mtDNA) into the T-cells meant to attack it. This sneaky move weakens the immune cells, making them less ...

Mitochondria dysfunction has been found to be involved in the development of diabetes in newly published research. Read more!

Walker, Ph.D, research assistant professor of internal medicine and first author of the study To do so, the team damaged three components that are essential for mitochondrial function: their DNA ...

To do so, the team damaged three components that are essential for mitochondrial function: their DNA, a pathway used to get ...