3D reconstruction of a microscope image: red is the membrane and green is clumped prion protein. In order to gain ... to explore the role of a membrane anchor on the folding and aggregation ...

A research team has now used new in vitro and cell culture models to show that a lipid anchor on the outer membrane of nerve cells inhibits the aggregation of the prion protein. Researchers have ...

More information: Kalpshree Gogte et al, Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases, Proceedings of the ...

Lipid anchors on nerve cell membranes stabilize prion protein folding, inhibiting aggregation. Membrane-anchored proteins clump only when exposed to pre-formed protein aggregates, simulating ...

The researchers conducted their experiments in samples of yeast with mutations, or alterations, in a mitochondrial membrane protein called AAC and samples of human cells that modeled a person with ...

(1) Degradation of mitochondria matrix, inner membrane and intermembrane oxidised or misfolded protein by mitochondrial proteases. (2) Ubiquitinated outer mitochondrial membrane proteins are ...

The study results, published June 5 in The EMBO Journal, shed new light, researchers say, on the way the altered ...

D. Hockenbery, G. Nunez, Curt Milliman, R.D. Schreiber, S.J. Korsmeyer, "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death," Nature, 348:334-36, 1990. David Hockenbery ...