Gary Gorbsky and colleagues managed to create conditions that make mitotic exit a reversible process 12. In the presence of a drug (MG132) that inhibits proteasome activity, cells cannot exit ...

4 Loss of mitotic exit checkpoints in cancer cells leads to mitotic dysregulation, resulting in aberrant proliferation 5.

Recently, through chemical and genetic trickery, Gary Gorbsky at the Oklahoma Medical Research Foundation and colleagues reversed the process. 1 They first triggered premature mitotic exit in Xenopus ...