A research team at the Institute for Basic Science (IBS) has identified a previously unknown enzyme, SIRT2, that plays a key ...

Unfortunately, we are just at the beginning of deciphering the cellular and molecular mechanisms that underlie neurotoxicity caused by soluble oligomers. It is clear that human neurodegeneration ...

The goal of our research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS).

Molecular Neurodegeneration. This advanced course covers several of the most important molecules involved in neurodegenerative disease, including Aβ, tau, apoE, TDP-43, α-synuclein, LRRK2, prion ...

Over half have mouse or human orthologues that are also associated with neurodegeneration. The swiss cheese (sws) gene demonstrates the value of unbiased screens in the fly. Since its discovery ...

We complement the C. elegans studies using mammalian cell culture and bioinformatic analysis of mouse and human deep sequencing data. See our detailed Molecular Biology of Neurodegeneration Lab ...

More information: Sonia Vazquez-Sanchez et al, Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS, Molecular Neurodegeneration (2024). DOI: 10.1186 ...

A nationwide team led by researchers at Baylor College of Medicine, Texas Children's Hospital and UPMC Children's Hospital of Pittsburgh has proposed a major revision to how Langerhans cell ...