Monoclonal antibodies (mAbs) are nature's biological ... are treated with other immunosuppressants and are less prone to HAMA reactions. If mAbs were to become a class of successful therapeutics ...

the clinical application of mouse monoclonal antibodies is limited by the human anti-mouse antibody (HAMA) response. Humanization of mouse monoclonal antibodies or alpaca nanobody by genetic ...

The mAbs that have been used in the clinic include murine, chimeric, humanized and fully human antibodies. In particular, chimerization consists of the replacement of the mouse constant domains ...

Data were summarized with the search of 'colorectal' and 'antibody' as of August 2012 at ClinicalTrials.gov [202]. EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors ...