an already-approved muscarinic antagonist designed to reduce M1/M4-related side effects in the peripheral nervous system. Meanwhile, Sosei Heptares also has a selective M4 agonist in early-stage ...

Muscarinic acetylcholine receptors (mAChRs) are a type of receptor in the brain that respond to the neurotransmitter acetylcholine. They play a crucial role in various brain functions, including ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

which combines muscarinic agonist xanomeline tartrate and muscarinic antagonist trospium chloride, as a treatment for adults with schizophrenia - a condition that affects around 3.9 million people ...

Umeclidinium is a long-acting muscarinic antagonist, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways ...

a once-daily medicine combining a long-acting muscarinic antagonist, umeclidinium bromide, LABA, VI. The company was founded by P. Roy Vagelos, Mathai Mammen, and George M. Whitesides in November ...