Rubisco is the enzyme responsible for carbon fixation in ... had substantially reduced catalytic rates compared with the non-mutant version. This observation is consistent with a trade-off between ...

Though SOD1 mutations are associated with fewer than two percent of overall instances of disease, an intense effort has focused on dissecting the mechanism through which this mutant enzyme ...

A new ML-guided platform can design thousands of new enzymes, predict how they will behave in the real world, and test their ...

natural selection acts in two directions on the hemizygous males- selecting for the mutant allele because it protects against malarial infection, yet selecting against it because an enzyme deficiency.

By comparing how these two versions worked, they were able to observe how the mutation changes the enzyme’s structure and how well the mutant enzyme functions. This research helped them ...

In addition, we are also modifying glycosidase enzymes (in collaboration with Dr. T.J. Borgford) with the aim of enabling the mutant enzymes to transfer unnatural glycosyl analogues onto biologically ...

The project will involve the generation of mutant libraries and high-throughput screening of mutant enzymes by fluorescence-activated cell-sorting and microtitre plate-based assays. In addition to the ...