Though SOD1 mutations are associated with fewer than two percent of overall instances of disease, an intense effort has focused on dissecting the mechanism through which this mutant enzyme ...

This result indicated that the R301Q mutant enzyme synthesized in the presence of DGJ was transported to the lysosome, the final destination of the enzyme. Figure 3: Subcellular fractionation of ...

"We did what's called a 'deep mutational scan' where you make every single amino acid mutant of the enzyme. It came out to a little under 9,000 mutants. Then we screened all of them in a pool ...

The project will involve the generation of mutant libraries and high-throughput screening of mutant enzymes by fluorescence-activated cell-sorting and microtitre plate-based assays. In addition to the ...

With its ability to specifically inhibit the mutant IDH1 enzyme, TIBSOVO addresses an unmet need in personalized cancer treatment, offering new hope for patients with limited options. As clinical ...