因此，在这项新研究中，研究团队探索了在人类 NK 细胞中利用 CRISPR-Cas9 基因编辑技术敲除 SMAD4 ，是否能够增强其对 TGFβ 的抗性，并通过利用 TGFβ 驱动的组织驻留特性来增强其抗肿瘤效力。

Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC ...

T细胞和NK细胞都是重要的免疫细胞。T细胞主要参与适应性免疫应答，而NK细胞是天然免疫系统的一部分，具有直接杀伤肿瘤细胞和病毒感染细胞的能力。它们在肿瘤免疫中体现出高度的互补性：T细胞可识别表达MHC-I的癌细胞，NK细胞则通过NK细胞受体（NCR）来识别MHC-I缺失的癌细胞。

Furthermore, mice on this diet for three weeks had smaller tumor volumes and reduced metastases compared to control mice. To assess whether NK cells were involved in antitumor response generated by ...

The genetic modification of the Natural Killer (NK) cells, lymphocytes forming part of the body’s immune system, would make it possible to retain ...

Among other functions, the NK cells (Natural Killers, a type of lymphocyte forming part of the immune system) have the capacity to detect and eliminate cancer cells. But in some cases they cannot ...

Human cervical carcinoma HeLa cells Significant macrophages and NK cell-mediated antitumor activity [131] OV-HM cells transfected with Ad-RGD-CCL19 Ovarian carcinoma OV-HM cells Significant tumor ...