Although they produce opposite effects on synaptic excitability, both LTP and LTD can occur at the same synapse in response to different patterns of activation of NMDA (N-methyl-D-aspartate ...

1月16日，团队在Cell杂志上首次以原子分辨率呈现出了内源NMDA受体的组装和结构；2月25日，上线Neuron杂志的论文揭示了镁离子调控NMDA受体的分子机制；3月5日，团队联合中国科学院上海药物研究所李扬/郭飞研究组在Science Advances杂志上证实了GluN2D亚型NMDA受体可成为快速抗抑郁药物的新靶点。

LTP requires the activity of NMDA (N-methyl-D-aspartate) receptors, which are composed of NR1 and NR2 subunits. The NR2B subunit is expressed at nascent synapses and is linked to enhanced ...

NMDA receptors, members of the excitatory ionotropic glutamate receptor family, are essential to these processes. They regulate the strength of synaptic connections, playing a critical role in ...