糖尿病足溃疡（DFU）治疗棘手，尚无特效药物。研究人员开展了 SIRT6 对 DFU 伤口愈合作用的研究。结果发现 SIRT6 过表达可加速 DFU 伤口愈合，其机制与激活 Nrf2 通路有关。该研究为 DFU 治疗提供了新靶点，具有重要临床意义。

与此同时，环境中的致癌物质，像化学污染物、辐射以及病毒感染等，也会对细胞的基因组造成损伤，为癌症的发生埋下隐患。 NRF2 的生物学功能 NRF2（Nuclear factor erythroid 2-related factor 2）作为一种转录调节因子，在细胞的生理和病理过程中占据着重要地位。

Carnosic acid activates the Nrf2 pathway, a key regulator of the body’s defense against oxidative stress and inflammation. While promising, its instability makes it unsuitable for therapeutic use.

Lipton’s group had previously determined that carnosic acid crosses the blood-brain barrier and activates the Nrf2 transcriptional pathway, which turns on antioxidant and anti-inflammatory genes. But ...

Lipton's group had previously determined that carnosic acid crosses the blood-brain barrier and activates the Nrf2 transcriptional pathway, which turns on antioxidant and anti-inflammatory genes.

The San Diego-based biotech's pipeline is headed by compounds that either block or activate NRF2, a transcription factor involved in immuno-inflammatory responses. Some forms of cancer are ...