Adjust the ionic composition and pH of the reaction mixture to suit the restriction enzyme, add 20 units of ... Rapidly add 300 μl of ice-cold nuclease S1 digestion buffer and immediately remove ...

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate ...

1| Pellet ∼10 8 cells at 300g at 4 °C for 10 min in a centrifuge. The nuclei should be kept cold throughout the procedure. Manipulations and transport to the centrifuge should be done on ice. 2 ...

Metagenomi says it hopes to start clinical trials next year to test MGX-001, its gene-editing therapy candidate for ...

Synthego granted global license to manufacture and distribute AZ's CRISPR gene editing enzyme, eSpOT-ON.

which happens when an enzyme called nuclease breaks down nucleic acids, such as DNA or RNA, into smaller fragments. The traditional way of identifying nuclease activity, Fluorescence Resonance ...

"By enhancing our CRISPR expertise with AstraZeneca's novel nuclease, we are poised to expedite ... upfront fees for rights to a leading CRISPR enzyme enabling therapeutic developers to de-risk ...