The first two drugs brought to market for treating COVID-19 were both nucleoside analogs." Meanwell and his team focused their approach on C4ʹ-modified nucleoside analogs, a particular subclass ...

Nucleoside analogues mimic the building blocks of DNA and RNA, allowing them to interfere with viral replication. Prodrugs, on the other hand, are chemically modified drugs that become active only ...

In this paper we review nucleoside analogues and nucleobases commonly used in the clinic, newly described compounds, and measures to improve the therapeutic indices of these drugs. Mechanisms of ...

Schematic diagram of the HIV–1 RT heterodimer in complex with double–stranded DNA (adapted from ref. 2). Figure 3: Sites of mutations conferring resistance to various nucleoside analog drugs.

In this paper we review nucleoside analogues and nucleobases commonly used in the clinic, newly described compounds, and measures to improve the therapeutic indices of these drugs. Mechanisms of ...

Department of Anesthesiology, Zhongnan Hospital of Wuhan University, TaiKang Center for Life and Medical Sciences, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China Key ...

The researchers predicted that PUM could have a "transformative" effect on treatment of bacterial infections, similar to that of certain analogous drugs (nucleoside analog inhibitors) on the treatment ...

Conclusions: Our analysis demonstrates that XMRV exhibits a distinct pattern of nucleoside analog susceptibility ... to a broader range of antiretroviral drugs than has previously been reported.

Typically, producing these analogs is complicated ... platform will serve as a route towards a greater range of nucleoside-based drugs," says Matthew Willmott, Manchester Institute of ...

Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...

Therefore, a computational approach is greatly desirable to understand the system. A biomedical application of this study will lead to a quantitative understanding of mitochondrial toxicity caused by ...