线粒体作为真核细胞的能量工厂和信号枢纽，其氧化磷酸化系统（OXPHOS）由呼吸复合体（CI-CV）、ATP合酶及辅助元件构成，不仅负责能量生产，还参与代谢调控与ROS生成。衰老过程中，OXPHOS系统表现出呼吸活性降低、酶活性下降、膜电位（ ψ）减弱、ATP合成减少 ...

Defects in the oxidative phosphorylation (OXPHOS) system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is ...

one subset containing P5CS (pyrroline-5-carboxylate synthase), which lacks cristae and adenosine triphosphate (ATP) synthase, and the other dedicated to OXPHOS. Read the full story here.