About half of the affected children have this type of OI. Few deformities and fractures occur due to mild to moderate trauma. Type II: This is the most severe form. This is generally found in ...

Constantinou, C.D., Nielsen, K.B. & Prockop, D.J. A lethal variant of osteogenesis imperfecta has a single base mutation that substitutes cystine for glycine 904 of the alpha (I) chain of type I ...

In our study 1, we reported engraftment of marrow-derived mesenchymal cells in the bones of children with severe OI undergoing an ... pilot study of this type, measurement of any single clinical ...