For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these ... Runt domain (a small β-strand) and p53 (a pair of antiparallel β-strands).

Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

It’s amazing that an individual point mutation could cause an entire organism to develop cancer. - Deborah Kelly, Pennsylvania State University They didn’t know what genes p53 regulated, so she and ...

The research team turned human cells senescent by exposing them to radiation and then used those cells to demonstrate that DNA fixer tumor protein p53 suppressed SASP and one of its triggering ...